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pentobarbital will lessen the extent or impact of ixabepilone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will lower the extent or result of clarithromycin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.If inducer is discontinued, consider oliceridine dosag